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10.1007/s12275-018-8024-4 194

Additionally, it has been discovered that C-KIT inhibitor imatinib harbors high efficacy against melanoma with KIT mutations, but not with KIT amplification only (54% vs 0% partial response) (148, 150)

For ATIKAs consolidated scientific framework, see the ATIKA White Paper

In this approach, the scaffold was also functionalized with azide groups, which enabled conjugation of the peptides to the TAC scaffold via CuAAC reaction (Scheme b)