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The hormone has a very short half-life of 12 minutes and is rapidly degraded by the enzyme dipeptidyl peptidase-4 (DPP-4) in circulation

This largely comes from bioavailability studies such as a randomized, controlled trial from 2018, which showed identical doses of ubiquinone and ubiquinol resulting in greater serum CoQ10 concentrations among the ubiquinol group.34 Thats certainly important, but it was a very small study (only ten participants), and it doesnt give us a sense of actual efficacy for any use case

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