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Methods SURMOUNT-2 participants were randomly assigned (1:1:1) to receive either tirzepatide 10 mg ( n = 312), tirzepatide 15 mg ( n = 311), or placebo ( n = 315) for 72 weeks as an adjunct to diet and exercise

IGF-1 replacement therapy induced a restoration of the altered GH/IGF-1 axis by reducing circulating GH levels and recovering the somatostatinergic tone [292]

Also, in the experiments on human breast cancer cells, Won and Seo found that the inactivation of PI3K/Akt/mTORC1 signaling pathway promotes the expression of caspases and Bax leading to increased apoptosis [302]

Officioso A, Manna C, Alzoubi K, Lang F