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Other syndromic traits were observed in both patients, including seizures, developmental delay, cognitive impairment, microcephalism, hypogonadism, dental abnormalities, and reticular skin pigmentation

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[148] Dependence and withdrawal Drug tolerance develops rapidly in amphetamine abuse (i.e., recreational amphetamine use), so periods of extended abuse require increasingly larger doses of the drug in order to achieve the same effect

Overview of the production and regulation of ROS ROS, which are highly reactive and short-lived molecules, readily engage with other cellular constituents, including lipids, proteins, and nucleic acids [10]