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Investigations suggest that peptides interacting with these receptors might influence neuroendocrine communication networks that coordinate hormonal rhythms, metabolic responses, and circadian regulation

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They can also penetrate pigmentation, which reduces the PDT treatment window's effectiveness by quenching ROS produced by PDT and by absorbing incident radiation [150]

Thus, although GIPR in the AP is required for the weight loss effects of GIPR agonists, it is not the target of therapeutic GIPR antagonists, supporting recent findings that Gipr KO in GABAergic neurons also abolished responses to GIPR agonism but not antagonism 6