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The same results were observed when applying APR-246 directly to cell lysate (Supplementary Fig

Biochemical investigations showed a normal level of cysteinyl glycine in plasma, an abnormal urinary profile with increased excretion of cysteinyl glycine (4972 mmol/mol of creatinine) and leukotrienes with increased leukotriene D4 and complete absence of LTE4

Headaches or mild dizziness, reported occasionally by users of various peptides

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