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Commonly used for blood sugar management, Metformin can interfere with how the small intestine absorbs B12

Critical limitations include: Heterogeneity : Different strains, doses, and formulations make comparisons difficult Small effect sizes : Weight changes are typically modest and may not be clinically significant Short duration : Most studies last 12 weeks or less, providing no data on sustained effects Publication bias : Negative studies may be underreported There is no high-quality evidence that probiotic supplements can replicate the substantial weight loss achieved with prescription medications like semaglutide or tirzepatide

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"Supports bone mineral density" - This is a DSHEA (Dietary Supplement Health and Education Act) structure/function claim