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For a complex molecule like Retatrutide, repeated freezing and thawing is generally not recommended unless specific protocols call for it

The primary mechanism of action involves binding to GLP-1 receptors located throughout the body, particularly in pancreatic beta cells, the gastrointestinal tract, and the central nervous system

However, in March 2025, Federal Health Minister Mark Butler wrote to the PBAC to seek their expert advice on equitable access to obesity medicines through the PBS, recognising the potential benefits but also the significant cost to the healthcare system of subsidising these medicines, the spokesperson told newsGP

Fifth, consideration of medical supervision is important