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The Safety Summary The Bottom Line For treating specific hyperpigmentation dark spots, PIH, melasma, uneven patches topical kojic acid has significantly stronger clinical evidence, a well-established safety profile, and a targeted mechanism that addresses the actual biology of those spots

These steps help providers confirm the treatment works and tweak it if needed

Ipamorelin according to scientific literature selectively releases growth hormone through specific receptor activation without significantly affecting other hormone systems in research models

1, 2026, but will continue covering the medication for Type 2 diabetes