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And unlike larger proteins, they tend to pass through the digestive tract intact

Researchers working with either compound should also consider downstream documentation requirements

The muscle of the upper arm (or the thigh or glute, alternatively) is injected with ~1mL (less than a full syringe) of B12

Often creates active metabolites Phase II metabolism: Conjugation, glucuronidation, acetylation etc Occurs in the liver and kidneys Involves other enzymes to CYP450 (various transferases) Often involves the addition of polar groups Often deactivates metabolites Excretion This involves the removal of the drug from the body