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58,59 It serves as a ligand for various receptor channels on the plasma membrane, including the zinc sensing receptor (ZnR/GPR39) that regulates neuronal excitation, 60 N-methyl-D-aspartate (NMDA) receptors, 61 -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, 62 voltage-dependent calcium channels (VDCC), 63 and -aminobutyric acid A (GABAA) receptors

Temperature fluctuation : Heat accelerates degradation significantly