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Collectively, these findings indicate that astaxanthin supports synaptic plasticity through coordinated functional, structural, and molecular mechanisms, providing a mechanistic basis for its reported cognitive benefits ( 3 Biochemical and molecular mechanisms in AD Alzheimers disease is considered a neurodegenerative disorder that is progressive and mainly affects cognition, such as disrupting memory, learning, and decision-making

S-glutathionylation of cysteine is a post-translational modification that alters protein activity 13

The sulfonamide 41 , like 23 (HA08) and 37 (HFI 419) increases spine density in primary cultures of hippocampal neurons but is unfortunately a too poor inhibitor of IRAP and is demonstrating a Ki value of 540 nM

Non-invasive Alternative: Nasal sprays provide a less invasive option than injections, potentially improving adherence in long-term research protocols