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A 2015 review of melanotan use and associated clinical outcomes identified eighteen clinical trials and twenty-one clinical case presentations demonstrating melanotan IIs action as a synthetic tanning agent [4]

doi: 10.1093/jn/117.1.99

In animal models, imaging studies and clinical trials, including those aimed at studying the effectiveness of GLP-1RAs for the treatment of dementia syndromes, have shown that in patients with insulin resistance and T2DM, as well as dementia, there is an energy deficiency of the brain, and the heterogeneity of changes in energy metabolism depending on dementia syndromes may affect the effectiveness of GLP-1RAs [23]

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