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Folic acid (FA)-induced AKI is one of the typical models simulating drug or toxicant-induced tubular injury, which is closely related to crystal formation in the tubule lumen and cellular oxidative stress, leading to massive inflammatory reaction and eventually tubular cell death (Martin-Sanchez et al., 2018)

In 2023, it placed adalimumab biosimilars (Hadlima, Hyrimoz) on preferred tier while moving Humira to non-preferred in several commercial plan segments, capturing rebate revenue from both AbbVie (which negotiated a defense rebate to protect Humiras tier) and from the biosimilar entrants seeking volume

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In: Feldman M, Friedman LS, Brand LJ (eds) Sleisenger and Fordtrans gastrointestinal and liver disease