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Establishment of a membrane contact site (MCS) between endosomal GLP-1R, ERMCS-localised VAPB and SPHKAP leads to the generation of a highly-localised cAMP/PKA signalling hub that triggers the PKA-dependent phosphorylation of the mitochondrial contact site and cristae organising system (MICOS) complex, mitochondrial remodelling, and improved mitochondrial function, leading to potentiation of insulin secretion and survival to ER stress downstream of GLP-1R action

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Anxiety on tirzepatide and muscle pain with tirzepatide have also been reported, though these are less common

In a statement, Scott Brunner, CEO of the Alliance for Pharmacy Compounding (APC), called the report concerning but incomplete