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International Journal of Molecular Sciences, 24(8), 4567-4582.
Given the robustness of this mitochondrial response, the multifaceted nature of PGC1 regulation in cells and a modest rescue at best by mTORC1 inhibition, we suspect that there is a degree of functional redundancy built into this metabolic plasticity system that can contribute to such an adaptive response, and complete inhibition of this system will prove difficult
8 and Supplementary Figs
Alongside this, the time of day variation in stroke onset exists, where theres a significant increase in morning onset strokes (Marler et al., 1989)
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