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When blood sugar improves quickly, the retinas diseased microvasculature may react in a way that temporarily worsens leakage, hemorrhage, or progression in some patients

First, digestion redirects blood flow from the oral mucosa to the GI tract, reducing the efficiency of sublingual uptake

Collectively, these observations support the benefits of calorie restriction and heighten the interest in pharmacologic agents, such as metformin, as calorie restriction mimetics

The biggest obstacle for the medications is the cost, said Pouya Shafipour, MD, a family and obesity medicine physician at Providence Saint Johns Health Center in California