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In vitro, PNA splenocytes and MLNs had reduced IL-5, IL-4, IL-13, and IL-10 production while IFN- was significantly increased upon B-FAHF-2 treatment [30]

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But it came with what researchers call "retinoid dermatitis": inflammation mediated by MCP-1 and IL-8 cytokine release, barrier disruption from transepidermal water loss, and photosensitivity from exposing fresh, immature cells to UV