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Semaglutide and tirzepatide studies show roughly two-thirds of lost weight returning within a year, with most regain in the first months and about one-third to 40% of the loss still held at one year. Retatrutide may produce greater regain pressure because its glucagon support for resting metabolism fades while appetite returns

The weight loss was comparable to that achieved with a 2.4 milligram dose of semaglutide injected once a week in the form of Wegovy over the same time frame, the company said in a statement

Together, they can contribute to an improved body composition, with reductions in both localized and overall body fat

BMI 30 with specific cardiovascular or kidney conditions