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The histological analysis of liver samples collected at 2 weeks post-PH revealed that the surviving mice of the MCD group presented elevated global NAS score, plasma ALT, intrahepatic TG and increased hepatic Fgf21 mRNA and serum levels of FGF21 (Fig

Those with PJS are at a much higher risk of developing several types of cancer, especially in the breast and gastrointestinal regions [77]

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Negative consequences of nutritional habits associated with a Western-style diet may lead to inflammation and production of free radicals (134) through the secretion of numerous pro-inflammatory molecules such as interleukin (IL)- 6, IL-1b, IL-8, and C-reactive protein (CRP), leading to the development of autoimmune disorders either directly, due to inflammation or disturbed immune balance, or indirectly due to increased fat depositions and the development of obesity