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Pharmacodynamically, its thyroid-stimulating activity demonstrated by increased thyroxine (T4) levels and decreased thyroid-stimulating hormone (TSH) poses a notable risk of iatrogenic thyrotoxicosis in patients with hyperthyroidism or autonomous thyroid tissue [231]

Novo Nordisk, the company that developed it, walked away in the early 2000s and never filed for approval

10.1073/pnas.170209797 119 StollE

6a, b) Delaying G6PDi-1 treatment for 1 h post-stimulation allowed for substantial cytokine production, indicating that G6PD and the PPP likely play an important role in the early signaling events following stimulation