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Mitochondria and cell death: outer membrane permeabilization and beyond

Patients in Hathaway et al.s study were recruited from a neuro-ophthalmology clinic at a tertiary care institute who very likely have significant underlying symptoms and neuro-ophthalmic diseases that distinctly differ from those of the general population taking GLP-1RAs, potentially causing a selection bias, they wrote

Furthermore, lixisenatide can cross the BBB at very low doses with obvious physiological activity, and promote neurogenesis in the CNS (58)