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In obesity-related HF with preserved ejection fraction (HFpEF), incretin-based therapy improves symptoms, physical function, and weight: semaglutide improved Kansas City Cardiomyopathy Questionnaire scores and exercise capacity in patients with and without diabetes in the STEP-HFpEF and STEP-HFpEF DM trials [43, 44], and tirzepatide reduced a composite of cardiovascular death or worsening HF, primarily driven by fewer HF events, in SUMMIT [45]

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