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Jay Campbell (03:04) Yes

In addition, melatonin can also initiate autophagy by inhibiting the AKT/mTOR activation to enhance the therapeutic effect of rapamycin on head and neck cancer (Shen et al., 2018) or prevent hypertrophic scar (Dong et al., 2023)

Both assays were performed with 0.1 mM NADPH and 1 U ml 1 GR

Enhancing mitophagy in such cells (experimentally via PINK1 overexpression) could reduce ROS and inflammasome activity, highlighting the tight link between mitochondrial quality control and immune cell inflammatory status (65)