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NYG2024146, NYG2024141)

Macrophage polarization defined as the conversion of M2-type macrophages to pro-inflammatory M1-type macrophages, represents a crucial phenotype in the DKD

Berberine has both antimicrobial and anti-inflammatory properties

Due to the continuous exposure to occlusal forces and periodontal microorganisms, alveolar bone possesses a unique immune microenvironment distinct from the long bones, with more frequent interactions between monocytes/macrophages and MSCs (Lin et al., 2021)