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The rat receptor was cloned by expression cloning of an islet cDNA library followed by identification of human clones (25, 26, 41, 111)

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Research has shown that BAs in combination with its activating transcription factor, farnesoid X receptor (FXR), inhibit cholesterol transport and increase cholesterol excretion by macrophages in order to reduce cholesterol concentration in plasma, and can be used as a therapeutic target for dyslipidemia (Figure 2

doi: 10.1186/s12862-018-1214-1 48 NunesSCRamosCLopes-CoelhoFSequeiraCOSilvaFGouveia-FernandesSet al