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H 2 O 2 , as a relatively stable ROS, can diffuse across cell membranes and cellular compartments, acting as an important second messenger molecule involved in regulating various physiological processes such as cell proliferation, differentiation, energy metabolism, and immune responses

(PubMed) Nantz MP, Rowe CA, Muller CE, Creasy RA, Stanilka JM, Percival SS

In addition, the authors note that the patients without Hunner lesions who had improvement did not improve to the same degree as patients with Hunner lesions

In addition, there was no significant difference in the degree of neuronal loss between male and female GCLC-KO mouse (Fig