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Prior approval and covered equivalents Helpful resources Medication Therapy Management See how you can get support from a pharmacist if you have complex prescription drug needs

Mechanistic studies suggest that the potential direct cardiovascular benefits of SGLT2i include augmentation of signal transducer and activator of transcription 3 (STAT3), inhibition of sodium hydrogen exchange (sodium-hydrogen antiporter 1 [NHE-1]), improved mitochondrial metabolism, modulation of natriuretic peptides, improved vascular stiffness and autonomic tone, reduction of inflammation, and improved cardiac energetics

Contraindication: Do not mix with other drugs