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Given that maintenance of normal glucose homeostasis also requires adequate substrate availability and metabolism, we performed and now report an unbiased metabolomics analysis of the plasma metabolome in the fasting state and in response to a standard mixed meal stimulus in individuals with PBH as compared with unaffected post-bariatric participants

Depending on dose and comparator, approximately 70-80% of the reduction in insulin resistance with semaglutide 0.5 mg and 34 to 94% with semaglutide 1.0 mg was attributable to changes in body weight

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