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Animal and test-tube studies indicate that they also affect tissue repair and wound healing ( Chapped lips are a common symptom of deficiencies, especially in folate (vitamin B9), riboflavin (vitamin B2), and vitamins B6 and B12 ( People with disorders that affect nutrient absorption such as celiac disease, chronic gastritis, and Crohns disease are especially susceptible to deficiencies ( Given that vitamin B12 is found primarily in animal products, vegans and vegetarians may also be at a higher risk of deficiency ( Furthermore, a deficiency in B vitamins may lead to dermatitis, depression, irritability, and fatigue ( summary Deficiencies in multiple nutrients, including iron, zinc, and B vitamins, can cause chapped lips

Finally, the dose-response of the genetically proxied GLP-1RAs may differ from that of the patient, so further studies are required to confirm this, and these findings should not promote the indiscriminate use of GLP-1RAs

Of a particular interest, poly(lactide-co-glycolide) (PLGA) is a biocompatible and biodegradable polyester, which is used in several FDA-approved products in the form of microspheres and other pharmaceutical dosage forms 2,3