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We induced APAP hepatotoxicity in mice either sufficient of serotonin (wild-type mice and TPH1-/- plus 5- Hydroxytryptophan (5-HTP)) or lacking peripheral serotonin ( Tph1-/- and wild-type mice plus p-chlorophenylalanine (PCPA)).Mice with sufficient 5-HT exposed to acetaminophen have a significantly lower mortality rate and a better outcome compared with mice deficient of 5-HT

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In rare instances, ovarian hyperstimulation syndrome can lead to life-threatening outcomes

Un essai de plus grande envergure, men sur 125 patients diabtiques de type 2 supplments 500 mg par jour pendant six mois, a confirm cette bonne tolrance