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Upon activation, microglia upregulate NADPH oxidase 2 which produces superoxide and inducible nitric oxide synthase, ultimately generating nitric oxide

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funding acquisition, G.S.-D., S.B., E.V

In the obese state, EAT expansion induces a pro-inflammatory and pro-oxidative cardiac microenvironment, promotes ectopic infiltration of cardiomyocytes, and thereby contributes to the development of insulin resistance, endothelial dysfunction, mitochondrial dysfunction, and myocardial fibrosis (63)