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10.1074/jbc.m210429200 34 ChenR.LimJ

Generally well-tolerated: Clinical trials report good safety profiles with parenteral L-Carnitine, even at high doses (up to 50 mg/kg IV daily) [5] [8]

Furthermore, PPP is the major pathway to generate NADPH [78], a main reducing agent protecting cells against oxidative stress and driving biosynthetic reactions such as amino acids, fatty acids, and nucleotide synthesis [79]

While obesity rates have remained stable over the past decade, rates of severe obesity have increased, from 7.7% to 9.7%