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Third, preclinical studies often lack standardized methodologies, limiting reproducibility

In addition, fumarate inhibits TET enzymes, which stimulate EMT, leading to cancer metastasis 131,132

While the mechanisms of caspase-dependent apoptosis are well-characterized in nucleated cells, their role in enucleated cells like erythrocytes remains less well understood

Targeting signalling pathways in Hepatocellular Carcinoma