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Nanotechnologys potential to transform RA management extends beyond high-income settings, offering scalable solutions to reduce the global burden of autoimmune diseases

159 The mitochondrial calcium uniporter (MCU) regulates Ca 2+ in mitochondria, and Ca 2+ uptake by MCU buffers the increase of cytoplasmic Ca 2+ and regulates mitochondrial oxidative phosphorylation

The broad appeal of these drugs is showcased by the Food and Drug Administrations approval of electrophilic drugs that act by forming covalent bonds against cancer-relevant targets such as BTK 30 , EGFR 31 or KRAS G12C (ref

For example, GA can trigger mitochondrial apoptotic signals: it upregulates Bax, downregulates Bcl-2, and activates caspase-9 and 3, leading to programmed cell death in various carcinoma cells (148)