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Unlike sedative-hypnotics that suppress REM sleep and create dependency, DSIP appears to support natural sleep architecture allowing normal progression through all sleep stages while specifically enhancing the deepest, most restorative phases

In a double-blind, randomized, placebo-controlled study, Ahmad et al 305 showed significant improvement over time in postdialysis asthenia in both L-carnitine-and placebo-treated patients

The lack of a single target has made DSIP harder to develop as a pharmaceutical, but the same versatility is partly why it has attracted research interest across different therapeutic areas

White WB, Cannon CP, Heller SR, Nissen SE, Bergenstal RM, Bakris GL, Perez AT, Fleck PR, Mehta CR, Kupfer S, Wilson C, Cushman WC, Zannad F: EXAMINE Investigators