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Among the enzymes related to GSH metabolism, glutathione S-transferases (GSTs, EC 2.5.1.18) catalyze the binding of various xenobiotics (including numerous pesticides) and their electrophilic metabolites with GSH to produce less toxic and more water-soluble conjugates, so this isoenzyme family has a distinct role in plant detoxification reactions (Marrs 1996, Edwards et al

doi: 10.1210/jc.2018-01713 51 ZongYDengKChongWP

The researchers used a method called propensity score matching to make sure both groups were similar in age, health conditions (like diabetes, high blood pressure, sleep apnea and arthritis), and medication use