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Mechanisms of Action of GLP-1RAs: Beyond Glycaemic Control Endogenous glucagon-like peptide-1 (GLP-1) is a peptide hormone secreted by intestinal L cells and brainstem neurons in response to nutrient intake

That non-scale victory kept me going, and the weight loss resumed two weeks later. Michael, 58, Type 2 diabetes patient The human body responds to GLP-1 medications in complex ways that extend far beyond weight

Related: Eli Lillys Tirzepatide Shows Promise for Keeping Prediabetic Patients Diabetes-Free Participants in the trial were randomly assigned to receive either Zepbound, Wegovy or a placebo, with results measured by weight loss percentage and improvements in metabolic health markers

[DOI] [PMC free article] [PubMed] [Google Scholar] 47.Igarashi T., Niwano S., Niwano H., Yoshizawa T., Nakamura H., Fukaya H., Fujiishi T., Ishizue N., Satoh A., Kishihara J., et al