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With the market arrival of oral Wegovy and Orforglipron , the risk for Stevanato appears evident: If patients transition to oral GLP-1 formulations, Stevanato will see a decline in orders for its subcutaneous injection packaging solutions

Interestingly, in SURPASS-4, the overall cohort of tirzepatide users and those with 30 mg/g UACR experienced an acute dip in eGFR at 12 weeks, resembling the eGFR slope observed in trials with semaglutide and other nephroprotective drugs, such as RAAS blockers [50] and SGLT-2i [51]

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Semaglutide has been shown to improve liver labs, modulate lipid metabolism, and lower hepatic inflammation, with effects that appear at least partly independent of weight loss