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Clinically defined and diagnosed as having a body mass index (BMI) exceeding 30 kg/m 2 , the condition has rapidly risen in the global human population from 4% in 1975 to an astounding 18% (more than quadruple) in 2016

reinhardtii variant ( Cr GPDH) decreased the total cellular NADH/NAD + ratio while its expression did not affect the total cellular NADPH/NADP + ratio ( Figure 1e-f , Supplementary Figure S3b-g )