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The Glucagon-Like Peptide-1 Receptor Agonist Exendin-4 Inhibits Lipopolysaccharide-Induced Osteoclast Formation and Bone Resorption via Inhibition of TNF-alpha Expression in Macrophages

For example, in clinical trials a GLP-1 analog (ROSE-010) significantly retarded gastric emptying in IBS patients, confirming that GLP-1 activity slows upper GI tract movement