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Additionally, some patients may experience reduced physical activity due to gastrointestinal side effects such as nausea or fatigue, which can inadvertently affect energy balance

Maybe, says Mikulik

Given the substantially larger size of the E3 ubiquitin-ligase family (over 600 members) compared to the more manageable number of USPs (~50 members), we focused on USPs to explore their involvement in regulating TGFBR1 in Sirt2 knockout (S2KO) cells

Clinicians should consider these differences, especially for patients struggling with both weight management and glycemic control, to optimize individualized treatment