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Therefore, research focusing on glutathione shows that this molecule plays a major role in protecting RPE cells against oxidative stress [36,48,49,50]

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Figure 2 Preclinical Results: Quantification of GSH, MDA, IL-6, TNF-, and IFN- Levels in Healthy Compared to T2DM Subjects For confirmation and demonstration of previous study findings, the levels of the reduced form of GSH, MDA, IL-6, TNF-, and IFN- were compared in healthy and T2DM groups and were measured in the plasma and RBCs isolated from peripheral blood of healthy and T2DM subjects

The results of western blot and immunofluorescence showed that knockdown of VRK2 resulted in the decline of SLC7A11 expression at PM (Fig