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Supplements are available that claim to be over-the-counter (OTC) alternatives to Ozempic, but there is minimal scientific evidence to prove they work effectively

Approval requires documented medical necessity, BMI thresholds (typically 27+ with comorbidities or 30+), and trial of metformin or other diabetes medications

However, ongoing maintenance therapy at lower doses or a personalized protocol can sustain results long-term

Thus, the reduced expression of esr1 in our retinal homogenates may reflect overall reduced levels of ER in zebrafish retina, though we were able to measure expression of esr1 in our homogenates