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Moreover, insulin resistance is a common pathogenic component of the development of metabolic syndrome, which is strongly associated with obesity

Mitsinikos T, Mrowczynski-Hernandez P, Kohli R

For example, a patient with type 2 diabetes on GLP-1 scheduled for hip replacement may continue the agent until 1 to 2 weeks pre-op if weight loss is modest, but stop earlier if gastroparesis or severe nausea is present