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However, therapeutic doses for treating deficiency range from high-dose oral supplements (1,0002,000 g daily) to intramuscular injections of 1 mg, particularly for pernicious anaemia or malabsorption conditions

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2.1 Renal Impairment Study 2.1.1 Study Population Male and female participants of non-childbearing potential were eligible for inclusion in the renal impairment study if they were aged between 18 and 80 years with a body mass index (BMI) between 20 and 39.9 kg/m 2 and a body weight 60 kg at screening

Developmental seizures and mortality result from reducing GABA A receptor alpha2-subunit interaction with collybistin