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In human retinal pigment epithelium cells, bilberry anthocyanins have been demonstrated to modulate the oxidative stress-protective enzymes glutathione S-transferase-pi and heme oxygenase-1 (HO-1) [269]

Assessing the effects of berberine is also difficult because the amounts and formulations of berberine used in different studies have varied widely, and most of the study participants had health problems, such as diabetes or fatty liver disease, that might have influenced the results

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