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In addition, single-cell transcriptomic analysis of a mouse model of hepatic ApoE3 knockout revealed that hepatic ApoE3 significantly upregulates genes associated with cell adhesion, synaptic plasticity, and carbohydrate metabolism [88, 90]

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SS-31 addresses the cellular energy consequences Who May Not Be Ideal Candidates Patients expecting immediate dramatic results: SS-31s benefits are cumulative and gradual patients who need immediate energy relief may respond better to NAD+ IV therapy as a faster-acting energy intervention while SS-31 builds longer-term mitochondrial support Patients with budget constraints requiring a single peptide: if only one mitochondrial peptide is in budget, NAD+ typically provides a broader immediate energy response