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A multidomain fusion protein in Listeria monocytogenes catalyzes the two primary activities for glutathione biosynthesis

It binds with high affinity to hepatocyte growth factor (HGF) and amplifies HGFs activity at its receptor, c-Met

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In addition, we elaborate on studies that have led to approval of the first FcRn antagonists, the clinical progress and structural design of molecules in the pipeline, their position in the overall therapeutic landscape of autoimmunity, the design of next-generation antagonists as well as the use of this receptor-targeting principle for other therapeutic applications