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57 On the other hand, the reduction in energy intake during an ad libitum lunch (buffet style) with tirzepatide 15 mg (348.4 kcal) was not significantly different compared to semaglutide 1 mg (284.1 kcal, P =0.19) which may suggest that mechanisms other than reduced food intake and appetite are contributed to the more WL observed with tirzepatide 15 mg versus semaglutide 1 mg